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» An alternative model of amino acid replacement
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ISMIS
2005
Springer
13 years 10 months ago
A Machine Text-Inspired Machine Learning Approach for Identification of Transmembrane Helix Boundaries
In this paper, we adapt a statistical learning approach, inspired by automated topic segmentation techniques in speech-recognized documents to the challenging protein segmentation ...
Betty Yee Man Cheng, Jaime G. Carbonell, Judith Kl...
BMCBI
2007
127views more  BMCBI 2007»
13 years 5 months ago
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines
Background: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The no...
Jian Tian, Ningfeng Wu, Xuexia Guo, Jun Guo, Juhua...
BMCBI
2006
120views more  BMCBI 2006»
13 years 5 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner
BMCBI
2007
135views more  BMCBI 2007»
13 years 5 months ago
Sequence similarity is more relevant than species specificity in probabilistic backtranslation
Background: Backtranslation is the process of decoding a sequence of amino acids into the corresponding codons. All synthetic gene design systems include a backtranslation module....
Alfredo Ferro, Rosalba Giugno, Giuseppe Pigola, Al...
BIBE
2005
IEEE
116views Bioinformatics» more  BIBE 2005»
13 years 11 months ago
Stochastic Model of Protease-Ligand Reactions
Prediction of protein tertiary structure based on amino acid sequence is one of the most challenging open questions in computational molecular biology. The two most common experim...
Paul E. Anderson, Douglas W. Raiford, Deacon J. Sw...