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» Analogue Circuit Control through Gene Expression
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BMCBI
2006
169views more  BMCBI 2006»
13 years 4 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....
GECCO
2007
Springer
131views Optimization» more  GECCO 2007»
13 years 11 months ago
Using feedback to regulate gene expression in a developmental control architecture
We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developme...
Kester Clegg, Susan Stepney, Tim Clarke
BMCBI
2007
169views more  BMCBI 2007»
13 years 5 months ago
Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and i
Background: Gene expression microarray and other multiplex data hold promise for addressing the challenges of cellular complexity, refined diagnoses and the discovery of well-targ...
Abdallah Sayyed-Ahmad, Kagan Tuncay, Peter J. Orto...
BMCBI
2010
240views more  BMCBI 2010»
13 years 5 months ago
CircuitsDB: a database of mixed microRNA/transcription factor feed-forward regulatory circuits in human and mouse
Background: Transcription Factors (TFs) and microRNAs (miRNAs) are key players for gene expression regulation in higher eukaryotes. In the last years, a large amount of bioinforma...
Olivier Friard, Angela Re, Daniela Taverna, Michel...
BMCBI
2006
132views more  BMCBI 2006»
13 years 4 months ago
Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by c
Background: Gene expression profiling using microarrays has become an important genetic tool. Spotted arrays prepared in academic labs have the advantage of low cost and high desi...
Xujing Wang, Shuang Jia, Lisa Meyer, Bixia Xiang, ...