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BMEI
2009
IEEE
13 years 5 months ago
Analysis of the Bipartite Networks of Domain Compositions and Metabolic Reactions
It is widely accepted that complexity of biological systems arises from combinations of common subunits. In this work we investigate the combinatorial patterns of protein domains ...
Chen-Hsiang Yeang
BIOCOMP
2009
13 years 5 months ago
Evolution of Domain Compositions in the Metabolic Networks of Human and Escherichia Coli
It is widely recognized that complexity of metabolic networks arises from duplication, recruitment and recombination of enzyme protein domains. However, variations of the domain ev...
Chen-Hsiang Yeang, Nils Baas
BIRD
2008
Springer
158views Bioinformatics» more  BIRD 2008»
13 years 6 months ago
A Computational Method for Reconstructing Gapless Metabolic Networks
Abstract. We propose a computational method for reconstructing metabolic networks. The method utilizes optimization techniques and graph traversal algorithms to discover a set of b...
Esa Pitkänen, Ari Rantanen, Juho Rousu, Esko ...
BMCBI
2006
118views more  BMCBI 2006»
13 years 4 months ago
Low degree metabolites explain essential reactions and enhance modularity in biological networks
Background: Recently there has been a lot of interest in identifying modules at the level of genetic and metabolic networks of organisms, as well as in identifying single genes an...
Areejit Samal, Shalini Singh, Varun Giri, Sandeep ...
BMCBI
2010
82views more  BMCBI 2010»
13 years 4 months ago
Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
Background: Metabolic pathway is a highly regulated network consisting of many metabolic reactions involving substrates, enzymes, and products, where substrates can be transformed...
Lei Chen, Kai-Yan Feng, Yu-Dong Cai, Kuo-Chen Chou...