67 search results - page 2 / 14 » CDD: a Conserved Domain Database for the functional annotati... |
BMCBI
2010
12 years 12 months ago
2010
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
NAR
2010
12 years 11 months ago
2010
The prediction of protein function as well as the reconstruction of evolutionary genesis employing sequence comparison at large is still the most powerful tool in sequence analysi...
BMCBI
2005
13 years 4 months ago
2005
Background: The functional sites of a protein present important information for determining its cellular function and are fundamental in drug design. Accordingly, accurate methods...
NAR
2007
13 years 4 months ago
2007
Protein domains are subunits of proteins that recur throughout the protein world. There are many definitions attempting to capture the essence of a protein domain, and several sys...
BMCBI
2007
13 years 5 months ago
2007
Background: Accurate sequence alignments are essential for homology searches and for building three-dimensional structural models of proteins. Since structure is better conserved ...