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» CoSMoS: Conserved Sequence Motif Search in the proteome
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GECCO
2006
Springer
159views Optimization» more  GECCO 2006»
13 years 8 months ago
Identification of weak motifs in multiple biological sequences using genetic algorithm
Recognition of motifs in multiple unaligned sequences provides an insight into protein structure and function. The task of discovering these motifs is very challenging because mos...
Topon Kumar Paul, Hitoshi Iba
BMCBI
2008
123views more  BMCBI 2008»
13 years 5 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...
BIBM
2009
IEEE
113views Bioinformatics» more  BIBM 2009»
13 years 8 months ago
Fast Motif Selection for Biological Sequences
—We consider the problem of identifying motifs, recurring or conserved patterns, in the sets of biological sequences. To solve this task, we present new deterministic and exact a...
Pavel P. Kuksa, Vladimir Pavlovic
IMSCCS
2006
IEEE
13 years 11 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
BIBE
2009
IEEE
126views Bioinformatics» more  BIBE 2009»
13 years 11 months ago
Mining Positional Association Super-Rules on Fixed-Size Protein Sequence Motifs
— Protein sequence motifs information is crucial to the analysis of biologically significant regions. The conserved regions have the potential to determine the role of the protei...
Bernard Chen, Sinan Kockara