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CIBB
2009
13 years 6 months ago
On the Use of Temporal Formal Logic to Model Gene Regulatory Networks
Modelling activities in molecular biology face the difficulty of prediction to link molecular knowledge with cell phenotypes. Even when the interaction graph between molecules is k...
Gilles Bernot, Jean-Paul Comet
ALIFE
2005
13 years 4 months ago
A Gene Network Model for Developing Cell Lineages
Biological development is a remarkably complex process. A single cell, in an appropriate environment, contains sufficient information to generate a variety of differentiated cell ...
Nicholas Geard, Janet Wiles
BMCBI
2008
115views more  BMCBI 2008»
13 years 5 months ago
Principal components analysis based methodology to identify differentially expressed genes in time-course microarray data
Background: Time-course microarray experiments are being increasingly used to characterize dynamic biological processes. In these experiments, the goal is to identify genes differ...
Sudhakar Jonnalagadda, Rajagopalan Srinivasan
BMCBI
2010
152views more  BMCBI 2010»
13 years 5 months ago
Comparative study of three commonly used continuous deterministic methods for modeling gene regulation networks
Background: A gene-regulatory network (GRN) refers to DNA segments that interact through their RNA and protein products and thereby govern the rates at which genes are transcribed...
Martin T. Swain, Johannes J. Mandel, Werner Dubitz...
BMCBI
2010
95views more  BMCBI 2010»
13 years 5 months ago
An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data
Background: ChIP-Seq, which combines chromatin immunoprecipitation (ChIP) with high-throughput massively parallel sequencing, is increasingly being used for identification of prot...
Congmao Wang, Jie Xu, Dasheng Zhang, Zoe A. Wilson...