Large-scale comparison of genomic DNA is of fundamental importance in annotating functional elements of genomes. To perform large comparisons efficiently, BLAST (Methods: Companio...
It is not unusual that an approximate model is needed for fitness evaluation in evolutionary computation. In this case, the convergence properties of the evolutionary algorithm are...
—Much of the computational complexity in employing evolutionary algorithms as optimization tool is due to the fitness function evaluation that may either not exist or be computat...
Mohsen Davarynejad, Mohammad R. Akbarzadeh-Totonch...
Abstract. Elevated temperatures cause proteins in living cells to misfold. They start forming larger and larger aggregates that can eventually lead to the cell's death. The he...
Elena Czeizler, Eugen Czeizler, Ralph-Johan Back, ...
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...