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BMCBI
2006
103views more  BMCBI 2006»
13 years 4 months ago
Correction of scaling mismatches in oligonucleotide microarray data
Background: Gene expression microarray data is notoriously subject to high signal variability. Moreover, unavoidable variation in the concentration of transcripts applied to micro...
Martino Barenco, Jaroslav Stark, Daniel Brewer, Da...
BIBE
2007
IEEE
115views Bioinformatics» more  BIBE 2007»
13 years 11 months ago
Semiparametric RMA Background-Correction for Oligonucleotide Arrays
—Microarray technology has provided an opportunity to simultaneously monitor the expression levels of a large number of genes in response to intentional perturbations. A necessar...
Ionut Bebu, Françoise Seillier-Moiseiwitsch...
BMCBI
2004
108views more  BMCBI 2004»
13 years 4 months ago
Improving the scaling normalization for high-density oligonucleotide GeneChip expression microarrays
Background: Normalization is an important step for microarray data analysis to minimize biological and technical variations. Choosing a suitable approach can be critical. The defa...
Chao Lu
BMCBI
2006
107views more  BMCBI 2006»
13 years 4 months ago
Evaluation of methods for oligonucleotide array data via quantitative real-time PCR
Background: There are currently many different methods for processing and summarizing probelevel data from Affymetrix oligonucleotide arrays. It is of great interest to validate t...
Li-Xuan Qin, Richard P. Beyer, Francesca N. Hudson...
BMCBI
2005
115views more  BMCBI 2005»
13 years 4 months ago
MPrime: efficient large scale multiple primer and oligonucleotide design for customized gene microarrays
Background: Enhancements in sequencing technology have recently yielded assemblies of large genomes including rat, mouse, human, fruit fly, and zebrafish. The availability of larg...
Eric C. Rouchka, Abdelnaby Khalyfa, Nigel G. F. Co...