16 search results - page 1 / 4 » Deconvolving sequence variation in mixed DNA populations |
RECOMB
2002
Springer
14 years 4 months ago
2002
Springer
We present an original approach to identifying sequence variants in a mixed DNA population from sequence trace data. The heart of the method is based on parsimony: given a wildtyp...
BMCBI
2011
12 years 8 months ago
2011
Background: With next-generation sequencing technologies, experiments that were considered prohibitive only a few years ago are now possible. However, while these technologies hav...
BMCBI
2007
13 years 4 months ago
2007
Background: Metagenomic analyses of microbial communities that are comprehensive enough to provide multiple samples of most loci in the genomes of the dominant organism types will...
BMCBI
2011
12 years 8 months ago
2011
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
BMCBI
2010
13 years 4 months ago
2010
Background: Copy number variants (CNVs) have been demonstrated to occur at a high frequency and are now widely believed to make a significant contribution to the phenotypic variat...