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» Detection of Variant Wipe Effects
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ISBI
2011
IEEE
12 years 9 months ago
Principal components regression: Multivariate, gene-based tests in imaging genomics
In imaging genomics, there have been rapid advances in genome-wide, image-wide searches for genes that influence brain structure. Most efforts focus on univariate tests that treat...
Derrek P. Hibar, Jason L. Stein, Omid Kohannim, Ne...
ISBI
2011
IEEE
12 years 9 months ago
Boosting power to detect genetic associations in imaging using multi-locus, genome-wide scans and ridge regression
Most algorithms used for imaging genetics examine statistical effects of each individual genetic variant, one at a time. We developed a new approach, based on ridge regression, to...
Omid Kohannim, Derrek P. Hibar, Jason L. Stein, Ne...
BMCBI
2011
13 years 24 days ago
Pathway-based analysis using reduced gene subsets in genome-wide association studies
Background: Single Nucleotide Polymorphism (SNP) analysis only captures a small proportion of associated genetic variants in Genome-Wide Association Studies (GWAS) partly due to s...
Jingyuan Zhao, Simone Gupta, Mark Seielstad, Jianj...
BMCBI
2011
12 years 9 months ago
A fast and accurate method to detect allelic genomic imbalances underlying mosaic rearrangements using SNP array data
Background: Mosaicism for copy number and copy neutral chromosomal rearrangements has been recently identified as a relatively common source of genetic variation in the normal pop...
Juan R. González, Benjamin Rodriguez-Santia...
ICST
2010
IEEE
13 years 4 months ago
Precisely Detecting Runtime Change Interactions for Evolving Software
Abstract—Developers often make multiple changes to software. These changes are introduced to work cooperatively or to accomplish separate goals. However, changes might not intera...
Raúl A. Santelices, Mary Jean Harrold, Ales...