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BMCBI
2006
95views more  BMCBI 2006»
13 years 4 months ago
Discrete profile comparison using information bottleneck
Sequence homologs are an important source of information about proteins. Amino acid profiles, representing the position-specific mutation probabilities found in profiles, are a ri...
Sean O'Rourke, Gal Chechik, Robin Friedman, Eleaza...
NIPS
2004
13 years 6 months ago
Discrete profile alignment via constrained information bottleneck
Amino acid profiles, which capture position-specific mutation probabilities, are a richer encoding of biological sequences than the individual sequences themselves. However, profi...
Sean O'Rourke, Gal Chechik, Robin Friedman, Eleaza...
SC
2000
ACM
13 years 9 months ago
Using Hardware Performance Monitors to Isolate Memory Bottlenecks
In this paper, we present and evaluate two techniques that use different styles of hardware support to provide data structure specific processor cache information. In one approach...
Bryan R. Buck, Jeffrey K. Hollingsworth
MICRO
1997
IEEE
90views Hardware» more  MICRO 1997»
13 years 8 months ago
ProfileMe: Hardware Support for Instruction-Level Profiling on Out-of-Order Processors
Profile data is valuable for identifying performance bottlenecks and guiding optimizations. Periodic sampling of a processor's performance monitoring hardware is an effective...
Jeffrey Dean, James E. Hicks, Carl A. Waldspurger,...
BMCBI
2007
106views more  BMCBI 2007»
13 years 4 months ago
Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive as
Background: A widely-used approach for discovering functional and physical interactions among proteins involves phylogenetic profile comparisons (PPCs). Here, proteins with simila...
Raja Jothi, Teresa M. Przytycka, L. Aravind