Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
The tertiary (3D) structure of a protein contains the essential information for understanding the biological function of the protein at the molecular and cellular levels. Traditio...
Manesh J. Shah, Sergei Passovets, Dongsup Kim, Kyl...
The Protein Information Resource (PIR; http://wwwnbrf.georgetown.edu/pir/ ) supports research on molecular evolution, functional genomics, and computational biology by maintaining...
Winona C. Barker, John S. Garavelli, Daniel H. Haf...
Background: Transcription factors (TFs) are core functional proteins which play important roles in gene expression control, and they are key factors for gene regulation network co...
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationsh...
Antonina Andreeva, Dave Howorth, John-Marc Chandon...