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» Estimate haplotype frequencies in pedigrees
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BMCBI
2006
117views more  BMCBI 2006»
13 years 5 months ago
The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
Cornelis A. Albers, Martijn A. R. Leisink, Hilbert...
BMCBI
2007
95views more  BMCBI 2007»
13 years 5 months ago
Haplotype-based score test for linkage in nuclear families
Background: To look for genetic linkage between angiotensin-I converting enzyme(ACE) gene and hypertension in a Korean adolescent cohort, we developed a powerful test using the co...
Chung Mo Nam, Dae Ryong Kang, Jinheum Kim
BMCBI
2010
100views more  BMCBI 2010»
13 years 5 months ago
Partitioning of copy-number genotypes in pedigrees
Background: Copy number variations (CNVs) and polymorphisms (CNPs) have only recently gained the genetic community's attention. Conservative estimates have shown that CNVs an...
Louis-Philippe Lemieux Perreault, Gregor U. Andelf...
ISBRA
2009
Springer
14 years 1 days ago
Imputation-Based Local Ancestry Inference in Admixed Populations
Abstract. Accurate inference of local ancestry from whole-genome genetic variation data is critical for understanding the history of admixed human populations and detecting SNPs as...
Bogdan Pasaniuc, Justin Kennedy, Ion I. Mandoiu