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ICASSP
2007
IEEE
13 years 11 months ago
Evolutionary Sequence Modeling for Discovery of Peptide Hormones
There are currently a large number of ‘‘orphan’’ G-protein-coupled receptors (GPCRs) whose endogenous ligands (peptide hormones) are unknown. Identification of these pepti...
M. Kemal Sönmez, Lawrence Toll, Nina Zaveri
ICAISC
2010
Springer
13 years 7 months ago
Computer Assisted Peptide Design and Optimization with Topology Preserving Neural Networks
Abstract. We propose a non-standard neural network called TPNN which offers the direct mapping from a peptide sequence to a property of interest in order to model the quantitative ...
Jörg D. Wichard, Sebastian Bandholtz, Carsten...
CSB
2005
IEEE
136views Bioinformatics» more  CSB 2005»
13 years 10 months ago
Whole Genome Phylogeny Based on Clustered Signature String Composition
Peptide compositions constructed out of whole sets of protein sequences can be used as species signatures for phylogenetic analysis. To account for point mutations, an amino acid ...
Xiaomeng Wu, Guohui Lin, Xiu-Feng Wan, Dong Xu
BMCBI
2011
12 years 8 months ago
Determinants of Antigenicity and Specificity in immune response for Protein Sequences
Background: Target specific antibodies are pivotal for the design of vaccines, immunodiagnostic tests, studies on proteomics for cancer biomarker discovery, identification of prot...
Yulong Wang, Wenjun Wu, Nicolas N. Negre, Kevin P....
GECCO
2005
Springer
119views Optimization» more  GECCO 2005»
13 years 10 months ago
A multi-objective evolutionary approach to peptide structure redesign and stabilization
The prediction of the native structures of proteins, the socalled protein folding problem, is a NP hard multi-minima optimization problem for which to date no routine solutions ex...
Tim Hohm, Daniel Hoffmann