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AUTOMATICA
2006
88views more  AUTOMATICA 2006»
13 years 4 months ago
Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways
A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as H gain. In general, however, it is ext...
Eduardo D. Sontag, Madalena Chaves
BMCBI
2008
138views more  BMCBI 2008»
13 years 4 months ago
Information transfer in signaling pathways: A study using coupled simulated and experimental data
Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite divers...
Jürgen Pahle, Anne K. Green, C. Jane Dixon, U...
BMCBI
2006
122views more  BMCBI 2006»
13 years 4 months ago
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks
Background:Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinator...
Holger Conzelmann, Julio Saez-Rodriguez, Thomas Sa...