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AUTOMATICA
2006

Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways

13 years 3 months ago
Exact computation of amplification for a class of nonlinear systems arising from cellular signaling pathways
A commonly employed measure of the signal amplification properties of an input/output system is its induced L2 norm, sometimes also known as H gain. In general, however, it is extremely difficult to compute the numerical value for this norm, or even to check that it is finite, unless the system being studied is linear. This paper describes a class of systems for which it is possible to reduce this computation to that of finding the norm of an associated linear system. In contrast to linearization approaches, a precise value, not an estimate, is obtained for the full nonlinear model. The class of systems that we study arose from the modeling of certain biological intracellular signaling cascades, but the results should be of wider applicability. Key words: Norms; Gains; Nonlinear systems; Signaling pathways
Eduardo D. Sontag, Madalena Chaves
Added 10 Dec 2010
Updated 10 Dec 2010
Type Journal
Year 2006
Where AUTOMATICA
Authors Eduardo D. Sontag, Madalena Chaves
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