Abstract. We describe a new method for the exploration of evolutionary relations between protein structures. The approach is based on the ESSM algorithm for detecting structural mu...
Background: The functional selection and three-dimensional structural constraints of proteins in nature often relates to the retention of significant sequence similarity between p...
Background: Detecting homology between remotely related protein families is an important problem in computational biology since the biological properties of uncharacterized protei...
Background: Detection of common evolutionary origin (homology) is a primary means of inferring protein structure and function. At present, comparison of protein families represent...
The Structural Classification of Proteins (SCOP) database provides a detailed and comprehensive description of the relationships of all known proteins structures. The classificati...
Loredana Lo Conte, Bart Ailey, Tim J. P. Hubbard, ...