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BMCBI
2007
123views more  BMCBI 2007»
13 years 5 months ago
Robust clustering in high dimensional data using statistical depths
Background: Mean-based clustering algorithms such as bisecting k-means generally lack robustness. Although componentwise median is a more robust alternative, it can be a poor cent...
Yuanyuan Ding, Xin Dang, Hanxiang Peng, Dawn Wilki...
CSB
2005
IEEE
156views Bioinformatics» more  CSB 2005»
13 years 11 months ago
A Robust Meta-classification Strategy for Cancer Diagnosis from Gene Expression Data
One of the major challenges in cancer diagnosis from microarray data is to develop robust classification models which are independent of the analysis techniques used and can combi...
Gabriela Alexe, Gyan Bhanot, Babu Venkataraghavan,...
BMCBI
2007
138views more  BMCBI 2007»
13 years 5 months ago
A full Bayesian hierarchical mixture model for the variance of gene differential expression
Background: In many laboratory-based high throughput microarray experiments, there are very few replicates of gene expression levels. Thus, estimates of gene variances are inaccur...
Samuel O. M. Manda, Rebecca E. Walls, Mark S. Gilt...
BMCBI
2006
200views more  BMCBI 2006»
13 years 5 months ago
Comparison and evaluation of methods for generating differentially expressed gene lists from microarray data
Background: Numerous feature selection methods have been applied to the identification of differentially expressed genes in microarray data. These include simple fold change, clas...
Ian B. Jeffery, Desmond G. Higgins, Aedín C...
BMCBI
2006
123views more  BMCBI 2006»
13 years 5 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger