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IJBRA
2007
88views more  IJBRA 2007»
13 years 4 months ago
Finding molecular complexes through multiple layer clustering of protein interaction networks
: Clustering protein-protein interaction networks (PINs) helps to identify complexes that guide the cell machinery. Clustering algorithms often create a flat clustering, without co...
Bill Andreopoulos, Aijun An, Xiangji Huang, Xiaoga...
BMCBI
2006
144views more  BMCBI 2006»
13 years 4 months ago
Development and implementation of an algorithm for detection of protein complexes in large interaction networks
Background: After complete sequencing of a number of genomes the focus has now turned to proteomics. Advanced proteomics technologies such as two-hybrid assay, mass spectrometry e...
Md. Altaf-Ul-Amin, Yoko Shinbo, Kenji Mihara, Ken ...
NAR
2011
216views Computer Vision» more  NAR 2011»
12 years 7 months ago
ChemProt: a disease chemical biology database
Systems pharmacology is an emergent area that studies drug action across multiple scales of complexity, from molecular and cellular to tissue and organism levels. There is a criti...
Olivier Taboureau, Sonny Kim Nielsen, Karine Audou...
BMCBI
2010
104views more  BMCBI 2010»
13 years 4 months ago
Analysis of protein-protein docking decoys using interaction fingerprints: application to the reconstruction of CaM-ligand compl
Background: Protein-protein docking for proteins with large conformational changes was analyzed by using interaction fingerprints, one of the scales for measuring similarities amo...
Nobuyuki Uchikoga, Takatsugu Hirokawa
IHI
2012
370views Healthcare» more  IHI 2012»
12 years 11 days ago
FUSE: a system for data-driven multi-level functional summarization of protein interaction networks
Despite recent progress in high-throughput experimental studies, systems level visualization and analysis of large protein interaction networks (ppi) remains a challenging task, g...
Boon-Siew Seah, Sourav S. Bhowmick, Charles Forbes...