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» GENOME: a rapid coalescent-based whole genome simulator
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UAI
2008
13 years 6 months ago
Feature Selection via Block-Regularized Regression
Identifying co-varying causal elements in very high dimensional feature space with internal structures, e.g., a space with as many as millions of linearly ordered features, as one...
Seyoung Kim, Eric P. Xing
APBC
2004
116views Bioinformatics» more  APBC 2004»
13 years 6 months ago
Structure-Function Relationship in DNA Sequence Recognition by Transcription Factors
Transcription factors play essential role in the gene regulation in higher organisms, binding to multiple target sequences and regulating multiple genes in a complex manner. In or...
Akinori Sarai, Samuel Selvaraj, M. Michael Gromiha...
BMCBI
2005
134views more  BMCBI 2005»
13 years 5 months ago
Ancestral sequence alignment under optimal conditions
Background: Multiple genome alignment is an important problem in bioinformatics. An important subproblem used by many multiple alignment approaches is that of aligning two multipl...
Alexander K. Hudek, Daniel G. Brown 0001
BMCBI
2007
219views more  BMCBI 2007»
13 years 5 months ago
MetaQTL: a package of new computational methods for the meta-analysis of QTL mapping experiments
Background: Integration of multiple results from Quantitative Trait Loci (QTL) studies is a key point to understand the genetic determinism of complex traits. Up to now many effor...
Jean-Baptiste Veyrieras, Bruno Goffinet, Alain Cha...
BMCBI
2010
165views more  BMCBI 2010»
13 years 5 months ago
Filtering, FDR and power
Background: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt ...
Maarten van Iterson, Judith M. Boer, Renée ...