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» GENOMEPOP: A program to simulate genomes in populations
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BMCBI
2008
111views more  BMCBI 2008»
13 years 4 months ago
GENOMEPOP: A program to simulate genomes in populations
Background: There are several situations in population biology research where simulating DNA sequences is useful. Simulation of biological populations under different evolutionary...
Antonio Carvajal-Rodríguez
CPM
2010
Springer
140views Combinatorics» more  CPM 2010»
13 years 9 months ago
Bounds on the Minimum Mosaic of Population Sequences under Recombination
We study the minimum mosaic problem, an optimization problem originated in population genomics. We develop a new lower bound, called the C bound. The C bound is provably higher and...
Yufeng Wu
BMCBI
2008
135views more  BMCBI 2008»
13 years 4 months ago
Fregene: Simulation of realistic sequence-level data in populations and ascertained samples
Background: FREGENE simulates sequence-level data over large genomic regions in large populations. Because, unlike coalescent simulators, it works forwards through time, it allows...
Marc Chadeau-Hyam, Clive J. Hoggart, Paul F. O'Rei...
BMCBI
2011
12 years 8 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu
ISMB
2000
13 years 6 months ago
A Practical Algorithm for Optimal Inference of Haplotypes from Diploid Populations
The next phase of human genomics will involve largescale screens of populations for signi cant DNA polymorphisms, notably single nucleotide polymorphisms SNP's. Dense human S...
Dan Gusfield