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13 years 6 months ago
Genomic Fold Assignment and Rational Modeling of Proteins of Biological Interest
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling an...
J. Michael Sauder, Roland L. Dunbrack Jr.
BMCBI
2005
97views more  BMCBI 2005»
13 years 4 months ago
Comparative mapping of sequence-based and structure-based protein domains
Background: Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independenc...
Ya Zhang, John-Marc Chandonia, Chris H. Q. Ding, S...
BMCBI
2006
202views more  BMCBI 2006»
13 years 5 months ago
DWARF - a data warehouse system for analyzing protein families
Background: The emerging field of integrative bioinformatics provides the tools to organize and systematically analyze vast amounts of highly diverse biological data and thus allo...
Markus Fischer, Quan K. Thai, Melanie Grieb, J&uum...
BMCBI
2008
126views more  BMCBI 2008»
13 years 5 months ago
Relating gene expression data on two-component systems to functional annotations in Escherichia coli
Background: Obtaining physiological insights from microarray experiments requires computational techniques that relate gene expression data to functional information. Traditionall...
Anne M. Denton, Jianfei Wu, Megan K. Townsend, Pre...