77 search results - page 2 / 16 » Global parameter estimation methods for stochastic biochemic... |
EVOW
2008
Springer
13 years 7 months ago
2008
Springer
A fundamental problem of modelling in Systems Biology is to precisely characterise quantitative parameters, which are hard to measure experimentally. For this reason, it is common ...
BMCBI
2006
13 years 5 months ago
2006
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
CDC
2008
IEEE
13 years 11 months ago
2008
IEEE
— Systems biologists are often faced with competing models for a given experimental system. Unfortunately, performing experiments can be time-consuming and expensive. Therefore, ...
RECOMB
2007
Springer
14 years 5 months ago
2007
Springer
Abstract. Given the substantial computational requirements of stochastic simulation, approximation is essential for efficient analysis of any realistic biochemical system. This pap...
BMCBI
2010
13 years 5 months ago
2010
Background: The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules, which can be...