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» Hidden conformations in protein structures
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RECOMB
2007
Springer
14 years 6 months ago
Protein Conformational Flexibility Analysis with Noisy Data
Abstract. Protein conformational changes play a critical role in biological functions such as ligand-protein and protein-protein interactions. Due to the noise in structural data, ...
Anshul Nigham, David Hsu
BMCBI
2006
143views more  BMCBI 2006»
13 years 5 months ago
Application of protein structure alignments to iterated hidden Markov model protocols for structure prediction
Background: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. Because ...
Eric D. Scheeff, Philip E. Bourne
ICPR
2006
IEEE
14 years 6 months ago
Protein Fold Recognition using a Structural Hidden Markov Model
Protein fold recognition has been the focus of computational biologists for many years. In order to map a protein primary structure to its correct 3D fold, we introduce in this pa...
Djamel Bouchaffra, Jun Tan
BMCBI
2006
84views more  BMCBI 2006»
13 years 5 months ago
Representation of target-bound drugs by computed conformers: implications for conformational libraries
Background: The increasing number of known protein structures provides valuable information about pharmaceutical targets. Drug binding sites are identifiable and suitable lead com...
Stefan Günther, Christian Senger, Elke Michal...
BMCBI
2006
102views more  BMCBI 2006»
13 years 5 months ago
Protein secondary structure prediction for a single-sequence using hidden semi-Markov models
Background: The accuracy of protein secondary structure prediction has been improving steadily towards the 88% estimated theoretical limit. There are two types of prediction algor...
Zafer Aydin, Yucel Altunbasak, Mark Borodovsky