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CSB
2005
IEEE
124views Bioinformatics» more  CSB 2005»
13 years 10 months ago
Identifying Local Gene Expression Patterns in Biomolecular Networks
This study is aimed at elucidating putative transcription regulators (TRs) responsible for the observed differential expression pattern. Combined direct promoter binding and indir...
Andrey Y. Sivachenko, Anton Yuryev, Nikolai Darase...
ITA
2006
167views Communications» more  ITA 2006»
13 years 4 months ago
Characterization of lung tumor subtypes through gene expression cluster validity assessment
The problem of assessing the reliability of clusters patients identified by clustering algorithms is crucial to estimate the significance of subclasses of diseases detectable at b...
Giorgio Valentini, Francesca Ruffino
BMCBI
2008
138views more  BMCBI 2008»
13 years 5 months ago
Methods for simultaneously identifying coherent local clusters with smooth global patterns in gene expression profiles
Background: The hierarchical clustering tree (HCT) with a dendrogram [1] and the singular value decomposition (SVD) with a dimension-reduced representative map [2] are popular met...
Yin-Jing Tien, Yun-Shien Lee, Han-Ming Wu, Chun-Ho...
BMCBI
2007
144views more  BMCBI 2007»
13 years 4 months ago
Accelerated search for biomolecular network models to interpret high-throughput experimental data
Background: The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein e...
Suman Datta, Bahrad A. Sokhansanj
BMCBI
2007
154views more  BMCBI 2007»
13 years 4 months ago
h-Profile plots for the discovery and exploration of patterns in gene expression data with an application to time course data
Background: An ever increasing number of techniques are being used to find genes with similar profiles from microarray studies. Visualization of gene expression profiles can aid t...
Yvonne E. Pittelkow, Susan R. Wilson