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BMCBI
2010
136views more  BMCBI 2010»
13 years 5 months ago
Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfa
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
RECOMB
2008
Springer
14 years 5 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
ICASSP
2008
IEEE
14 years 14 hour ago
Mutual information based relevance network analysis: a Parkinson'S disease study
Monitoring the dynamics of networks in the brain is of central importance in normal and disease states. Current methods of detecting networks in the recorded EEG such as correlati...
Pamela Wen-Hsin Lee, Z. Jane Wang, Martin J. McKeo...
KDD
2008
ACM
213views Data Mining» more  KDD 2008»
14 years 6 months ago
Heterogeneous data fusion for alzheimer's disease study
Effective diagnosis of Alzheimer's disease (AD) is of primary importance in biomedical research. Recent studies have demonstrated that neuroimaging parameters are sensitive a...
Jieping Ye, Kewei Chen, Teresa Wu, Jing Li, Zheng ...
RECOMB
2009
Springer
14 years 6 months ago
COE: A General Approach for Efficient Genome-Wide Two-Locus Epistasis Test in Disease Association Study
The availability of high density single nucleotide polymorphisms (SNPs) data has made genome-wide association study computationally challenging. Twolocus epistasis (gene-gene inter...
Xiang Zhang, Feng Pan, Yuying Xie, Fei Zou, Wei Wa...