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HAIS
2009
Springer
13 years 9 months ago
Incremental Kernel Machines for Protein Remote Homology Detection
Abstract. Protein membership prediction is a fundamental task to retrieve information for unknown or unidentified sequences. When support vector machines (SVMs) are associated with...
Lionel Morgado, Carlos Pereira
JCB
2000
107views more  JCB 2000»
13 years 4 months ago
A Discriminative Framework for Detecting Remote Protein Homologies
A new method for detecting remote protein homologies is introduced and shown to perform well in classifying protein domains by SCOP superfamily. The method is a variant of support...
Tommi Jaakkola, Mark Diekhans, David Haussler
BMCBI
2007
144views more  BMCBI 2007»
13 years 4 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...
BIOINFORMATICS
2005
140views more  BIOINFORMATICS 2005»
13 years 4 months ago
Profile-based direct kernels for remote homology detection and fold recognition
Motivation: Remote homology detection between protein sequences is a central problem in computational biology. Supervised learning algorithms based on support vector machines are ...
Huzefa Rangwala, George Karypis
RECOMB
2002
Springer
14 years 5 months ago
Combining pairwise sequence similarity and support vector machines for remote protein homology detection
One key element in understanding the molecular machinery of the cell is to understand the meaning, or function, of each protein encoded in the genome. A very successful means of i...
Li Liao, William Stafford Noble