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BMCBI
2010
172views more  BMCBI 2010»
13 years 5 months ago
Comparison of evolutionary algorithms in gene regulatory network model inference
Background: The evolution of high throughput technologies that measure gene expression levels has created a data base for inferring GRNs (a process also known as reverse engineeri...
Alina Sîrbu, Heather J. Ruskin, Martin Crane
BMCBI
2010
172views more  BMCBI 2010»
13 years 6 days ago
Nonparametric identification of regulatory interactions from spatial and temporal gene expression data
Background: The correlation between the expression levels of transcription factors and their target genes can be used to infer interactions within animal regulatory networks, but ...
Anil Aswani, Soile V. E. Keränen, James Brown...
BMCBI
2008
166views more  BMCBI 2008»
13 years 5 months ago
Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual informa
Background: Probability based statistical learning methods such as mutual information and Bayesian networks have emerged as a major category of tools for reverse engineering mecha...
Weijun Luo, Kurt D. Hankenson, Peter J. Woolf
WABI
2009
Springer
128views Bioinformatics» more  WABI 2009»
13 years 11 months ago
Improving Inference of Transcriptional Regulatory Networks Based on Network Evolutionary Models
Abstract. Computational inference of transcriptional regulatory networks remains a challenging problem, in part due to the lack of strong network models. In this paper we present e...
Xiuwei Zhang, Bernard M. E. Moret
BMCBI
2008
129views more  BMCBI 2008»
13 years 5 months ago
Motif-directed network component analysis for regulatory network inference
Background: Network Component Analysis (NCA) has shown its effectiveness in discovering regulators and inferring transcription factor activities (TFAs) when both microarray data a...
Chen Wang, Jianhua Xuan, Li Chen, Po Zhao, Yue Wan...