Background: The genomewide pattern of changes in mRNA expression measured using DNA microarrays is typically a complex superposition of the response of multiple regulatory pathway...
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...
Inferring transcriptional regulatory networks from geneexpression data remains a challenging problem, in part because of the noisy nature of the data and the lack of strong networ...
Disease occurs due to aberrant modulation of biological pathways. Identification of activated gene pathways from gene expression data is an important problem. In this work, we de...
Biochemical pathways such as metabolic, regulatory or signal tranduction pathways can be viewed as interconnected processes forming an intricate network of functional and physical...
Yves Deville, David Gilbert, Jacques van Helden, S...