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2008
IEEE
13 years 11 months ago
Inferring the Function of Genes from Synthetic Lethal Mutations
—Techniques for detecting synthetic lethal mutations in double gene deletion experiments are emerging as powerful tool for analysing genes in parallel or overlapping pathways wit...
Oliver Ray, Christopher H. Bryant
BMCBI
2005
169views more  BMCBI 2005»
13 years 4 months ago
Genetic interaction motif finding by expectation maximization - a novel statistical model for inferring gene modules from synthe
Background: Synthetic lethality experiments identify pairs of genes with complementary function. More direct functional associations (for example greater probability of membership...
Yan Qi 0003, Ping Ye, Joel S. Bader
BIOINFORMATICS
2010
99views more  BIOINFORMATICS 2010»
12 years 11 months ago
Gene function prediction from synthetic lethality networks via ranking on demand
Christoph Lippert, Zoubin Ghahramani, Karsten M. B...
BMCBI
2008
95views more  BMCBI 2008»
13 years 4 months ago
Mining protein networks for synthetic genetic interactions
Background: The local connectivity and global position of a protein in a protein interaction network are known to correlate with some of its functional properties, including its e...
Sri R. Paladugu, Shan Zhao, Animesh Ray, Alpan Rav...
BMCBI
2010
179views more  BMCBI 2010»
13 years 4 months ago
A semi-supervised learning approach to predict synthetic genetic interactions by combining functional and topological properties
Background: Genetic interaction profiles are highly informative and helpful for understanding the functional linkages between genes, and therefore have been extensively exploited ...
Zhuhong You, Zheng Yin, Kyungsook Han, De-Shuang H...