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BIBE
2007
IEEE
125views Bioinformatics» more  BIBE 2007»
13 years 11 months ago
Large-scale Discovery of Regulatory Motifs Involved in Alternative Splicing
Alternative splicing is a highly important process in many eukaryotic organisms, but surprisingly little is known about its regulation. Often, this process involves cis-regulatory ...
Sihui Zhao, Jihye Kim, Steffen Heber
ACMSE
2007
ACM
13 years 9 months ago
Finding association rules of cis-regulatory elements involved in alternative splicing
Alternative splicing (AS) is a major mechanism to generate protein diversity. A single gene might generate hundreds or even thousands of different proteins. Recently, powerful lar...
Jihye Kim, Sihui Zhao, Steffen Heber
ISBRA
2009
Springer
13 years 11 months ago
Analysis of Cis-Regulatory Motifs in Cassette Exons by Incorporating Exon Skipping Rates
Identification of cis-regulatory motifs has long been a hotspot in the study of alternative splicing. We propose a two-step approach: we first identify k-mer seed motifs by testing...
Sihui Zhao, Jihye Kim, Steffen Heber
ISBRA
2009
Springer
13 years 11 months ago
Mining of cis-Regulatory Motifs Associated with Tissue-Specific Alternative Splicing
KIM, JIHYE. Mining of Cis-Regulatory Motifs Associated with Tissue-Specific Alternative Splicing. (Under the direction of Steffen Heber). Alternative splicing (AS) is an important...
Jihye Kim, Sihui Zhao, Brian E. Howard, Steffen He...
BMCBI
2006
75views more  BMCBI 2006»
13 years 4 months ago
A machine learning strategy to identify candidate binding sites in human protein-coding sequence
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...
Thomas Down, Bernard Leong, Tim J. P. Hubbard