Alternative splicing is a highly important process in many eukaryotic organisms, but surprisingly little is known about its regulation. Often, this process involves cis-regulatory ...
Alternative splicing (AS) is a major mechanism to generate protein diversity. A single gene might generate hundreds or even thousands of different proteins. Recently, powerful lar...
Identification of cis-regulatory motifs has long been a hotspot in the study of alternative splicing. We propose a two-step approach: we first identify k-mer seed motifs by testing...
KIM, JIHYE. Mining of Cis-Regulatory Motifs Associated with Tissue-Specific Alternative Splicing. (Under the direction of Steffen Heber). Alternative splicing (AS) is an important...
Jihye Kim, Sihui Zhao, Brian E. Howard, Steffen He...
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...