Background: Existing tools for multiple-sequence alignment focus on aligning protein sequence or protein-coding DNA sequence, and are often based on extensions to Needleman-Wunsch...
Multiple sequence alignment is a fundamental problem in computational biology. Because of its notorious difficulties, aligning sequences within a constant band (c-diagonal) is a ...
The field of algorithms for pairwisc biosequence similarity search is dominated by heuristic methods of high efficiency but uncertain sensitivity. One reason that more formal stri...
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Background: Over the past decade, a number of tools have emerged for the examination of homology relationships among protein sequences in a structural context. Most recent softwar...