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» MS4 - Multi-Scale Selector of Sequence Signatures: An alignm...
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BMCBI
2008
156views more  BMCBI 2008»
13 years 5 months ago
The unique probe selector: a comprehensive web service for probe design and oligonucleotide arrays
Background: Nucleic acid hybridization, a fundamental technique in molecular biology, can be modified into very effective and sensitive methods for detecting particular targets mi...
Shu-Hwa Chen, Chen-Zen Lo, Ming-Chi Tsai, Chao A. ...
BMCBI
2008
132views more  BMCBI 2008»
13 years 5 months ago
The Average Mutual Information Profile as a Genomic Signature
Background: Occult organizational structures in DNA sequences may hold the key to understanding functional and evolutionary aspects of the DNA molecule. Such structures can also p...
Mark Bauer, Sheldon M. Schuster, Khalid Sayood
BMCBI
2002
133views more  BMCBI 2002»
13 years 4 months ago
Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model app
Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
Kevin Truong, Mitsuhiko Ikura
BMCBI
2010
123views more  BMCBI 2010»
12 years 12 months ago
Predicting conserved protein motifs with Sub-HMMs
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Kevin Horan, Christian R. Shelton, Thomas Girke
BMCBI
2007
116views more  BMCBI 2007»
13 years 4 months ago
Linear array of conserved sequence motifs to discriminate protein subfamilies: study on pyridine nucleotide-disulfide reductases
Background: The pyridine nucleotide disulfide reductase (PNDR) is a large and heterogeneous protein family divided into two classes (I and II), which reflect the divergent evoluti...
César L. Avila, Viviana A. Rapisarda, Ricar...