— A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucle...
Motivation: Over 50% of human genes contain CpG islands in their 5'-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulatio...
Fang Fang, Shicai Fan, Xuegong Zhang, Michael Q. Z...
Background: Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation o...
Leandro A. Loss, Anguraj Sadanandam, Steffen Durin...
Background: Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defini...
Michael Hackenberg, Christopher Previti, Pedro Lui...
We describe PReMod, a new database of genomewide cis-regulatory module (CRM) predictions for both the human and the mouse genomes. The prediction algorithm, described previously i...
Vincent Ferretti, Christian Poitras, Dominique Ber...