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» Modeling dependencies in protein-DNA binding sites
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BMCBI
2008
100views more  BMCBI 2008»
13 years 5 months ago
Extracting transcription factor binding sites from unaligned gene sequences with statistical models
Background: Transcription factor binding sites (TFBSs) are crucial in the regulation of gene transcription. Recently, chromatin immunoprecipitation followed by cDNA microarray hyb...
Chung-Chin Lu, Wei-Hao Yuan, Te-Ming Chen
ICASSP
2008
IEEE
13 years 11 months ago
Modeling regulatory sites with higher order position-dependent weight matrices
Identification of regulatory signals in DNA depends on the nature and quality of the patterns of representative sequences. These patterns are constructed from training sets of se...
Hossein Zare, Mostafa Kaveh, Arkady B. Khodursky
BMCBI
2010
153views more  BMCBI 2010»
13 years 5 months ago
Metamotifs - a generative model for building families of nucleotide position weight matrices
Background: Development of high-throughput methods for measuring DNA interactions of transcription factors together with computational advances in short motif inference algorithms...
Matias Piipari, Thomas A. Down, Tim J. P. Hubbard
TCBB
2008
103views more  TCBB 2008»
13 years 5 months ago
DNA Motif Representation with Nucleotide Dependency
The problem of discovering novel motifs of binding sites is important to the understanding of gene regulatory networks. Motifs are generally represented by matrices (PWM or PSSM) o...
Francis Y. L. Chin, Henry C. M. Leung