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BMCBI
2010
95views more  BMCBI 2010»
13 years 4 months ago
Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets
Background: Theme-driven cancer survival studies address whether the expression signature of genes related to a biological process can predict patient survival time. Although this...
Esteban Czwan, Benedikt Brors, David Kipling
RECOMB
2008
Springer
14 years 5 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
BMCBI
2010
97views more  BMCBI 2010»
12 years 11 months ago
A semi-parametric Bayesian model for unsupervised differential co-expression analysis
Background: Differential co-expression analysis is an emerging strategy for characterizing disease related dysregulation of gene expression regulatory networks. Given pre-defined ...
Johannes M. Freudenberg, Siva Sivaganesan, Michael...
BMCBI
2005
93views more  BMCBI 2005»
13 years 4 months ago
Identification of novel prognostic markers in cervical intraepithelial neoplasia using LDMAS (LOH Data Management and Analysis S
Background: Detection of Loss of Heterozygosity (LOH) is one of the most common molecular applications in the study of human diseases, in particular cancer. The technique is commo...
Rifat A. Hamoudi, Amina El-Hamidi, Ming-Qing Du
BMCBI
2011
12 years 11 months ago
The PathOlogist: An Automated Tool for Pathway-Centric Analysis
Background: The PathOlogist is a new tool designed to transform large sets of gene expression data into quantitative descriptors of pathway-level behavior. The tool aims to provid...
Sharon I. Greenblum, Sol Efroni, Carl F. Schaefer,...