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RECOMB
2009
Springer
14 years 5 months ago
Parameter Synthesis in Nonlinear Dynamical Systems: Application to Systems Biology
The dynamics of biological processes are often modeled as systems of nonlinear ordinary differential equations (ODE). An important feature of nonlinear ODEs is that seemingly minor...
Alexandre Donzé, Gilles Clermont, Axel Lega...
CAV
2010
Springer
227views Hardware» more  CAV 2010»
13 years 2 months ago
Breach, A Toolbox for Verification and Parameter Synthesis of Hybrid Systems
We describe Breach, a Matlab toolbox providing a coherent set of simulation-based techniques aimed at the analysis of deterministic models of hybrid dynamical systems. The primary ...
Alexandre Donzé
BMCBI
2006
194views more  BMCBI 2006»
13 years 4 months ago
Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
BMCBI
2008
160views more  BMCBI 2008»
13 years 5 months ago
Dynamic sensitivity analysis of biological systems
Background: A mathematical model to understand, predict, control, or even design a real biological system is a central theme in systems biology. A dynamic biological system is alw...
Wu Hsiung Wu, Feng Sheng Wang, Maw Shang Chang
HYBRID
2009
Springer
13 years 11 months ago
Parameter Synthesis for Hybrid Systems with an Application to Simulink Models
Abstract. This paper addresses a parameter synthesis problem for nonlinear hybrid systems. Considering a set of uncertain parameters and a safety property, we give an algorithm tha...
Alexandre Donzé, Bruce H. Krogh, Akshay Raj...