115 search results - page 3 / 23 » Parameters for accurate genome alignment |
BMCBI
2010
13 years 2 months ago
2010
Background: Traditional genome alignment methods consider sequence alignment as a variation of the string edit distance problem, and perform alignment by matching characters of th...
RECOMB
2006
Springer
14 years 5 months ago
2006
Springer
It is well known that the base composition along eukaryotic genomes is long-range correlated. Here, we investigate the effect of such long-range correlations on alignment score sta...
BMCBI
2004
13 years 5 months ago
2004
Background: Rates of substitution in protein-coding sequences can provide important insights into evolutionary processes that are of biomedical and theoretical interest. Increased...
BMCBI
2008
13 years 5 months ago
2008
Background: Identification of RNA homologs within genomic stretches is difficult when pairwise sequence identity is low or unalignable flanking residues are present. In both cases...
BMCBI
2006
13 years 5 months ago
2006
Background: ESTs are a tremendous resource for determining the exon-intron structures of genes, but even extensive EST sequencing tends to leave many exons and genes untouched. Ge...