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» Pattern discovery in sequences under a Markov assumption
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BMCBI
2008
144views more  BMCBI 2008»
13 years 5 months ago
Local conservation scores without a priori assumptions on neutral substitution rates
Background: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed...
Janis Dingel, Pavol Hanus, Niccolò Leonardi...
BMCBI
2006
87views more  BMCBI 2006»
13 years 5 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
TCBB
2010
98views more  TCBB 2010»
13 years 11 days ago
VARUN: Discovering Extensible Motifs under Saturation Constraints
Abstract-The discovery of motifs in biosequences is frequently torn between the rigidity of the model on the one hand and the abundance of candidates on the other. In particular, m...
Alberto Apostolico, Matteo Comin, Laxmi Parida
TASLP
2008
141views more  TASLP 2008»
13 years 5 months ago
Unsupervised Pattern Discovery in Speech
We present a novel approach to speech processing based on the principle of pattern discovery. Our work represents a departure from traditional models of speech recognition, where t...
A. S. Park, J. R. Glass
BMCBI
2005
100views more  BMCBI 2005»
13 years 5 months ago
Speeding disease gene discovery by sequence based candidate prioritization
Background: Regions of interest identified through genetic linkage studies regularly exceed 30 centimorgans in size and can contain hundreds of genes. Traditionally this number is...
Euan A. Adie, Richard R. Adams, Kathryn L. Evans, ...