Sciweavers

78 search results - page 1 / 16
» Prediction of Enzyme Catalytic Sites from Sequence Using Neu...
Sort
View
CIBCB
2007
IEEE
13 years 8 months ago
Prediction of Enzyme Catalytic Sites from Sequence Using Neural Networks
The accurate prediction of enzyme catalytic sites remains an open problem in bioinformatics. Recently, several structure-based methods have become popular; however, few robust seq...
Swati Pande, Amar Raheja, Dennis R. Livesay
BMCBI
2007
89views more  BMCBI 2007»
13 years 4 months ago
Selective prediction of interaction sites in protein structures with THEMATICS
Background: Methods are now available for the prediction of interaction sites in protein 3D structures. While many of these methods report high success rates for site prediction, ...
Ying Wei, Jaeju Ko, Leonel F. Murga, Mary Jo Ondre...
BMCBI
2007
115views more  BMCBI 2007»
13 years 4 months ago
How accurate and statistically robust are catalytic site predictions based on closeness centrality?
Background: We examine the accuracy of enzyme catalytic residue predictions from a network representation of protein structure. In this model, amino acid α-carbons specify vertic...
Eric Chea, Dennis R. Livesay
BMCBI
2008
103views more  BMCBI 2008»
13 years 4 months ago
Detection of protein catalytic residues at high precision using local network properties
Background: Identifying the active site of an enzyme is a crucial step in functional studies. While protein sequences and structures can be experimentally characterized, determini...
Patrick Slama, Ioannis Filippis, Michael Lappe
BMCBI
2005
97views more  BMCBI 2005»
13 years 4 months ago
Sequence variation in ligand binding sites in proteins
Background: The recent explosion in the availability of complete genome sequences has led to the cataloging of tens of thousands of new proteins and putative proteins. Many of the...
Thomas J. Magliery, Lynne Regan