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» Probabilistic Model Checking of Complex Biological Pathways
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ENTCS
2002
125views more  ENTCS 2002»
13 years 4 months ago
Pathway Logic: Executable Models of Biological Networks
In this paper we describe the use of the rewriting logic based Maude tool to model and analyze mammalian signaling pathways. We discuss the representation of the underlying biolog...
Steven Eker, Merrill Knapp, Keith Laderoute, Patri...
AIPS
2003
13 years 6 months ago
A Multi-Agent System-driven AI Planning Approach to Biological Pathway Discovery
As genomic and proteomic data is collected from highthroughput methods on a daily basis, subcellular components are identified and their in vitro behavior is characterized. Howev...
Salim Khan, William Gillis, Carl Schmidt, Keith De...
RP
2009
Springer
136views Control Systems» more  RP 2009»
13 years 11 months ago
Probabilistic Model Checking of Biological Systems with Uncertain Kinetic Rates
We present an abstraction of the probabilistic semantics of Multiset Rewriting to formally express systems of reactions with uncertain kinetic rates. This allows biological systems...
Roberto Barbuti, Francesca Levi, Paolo Milazzo, Gu...
CMSB
2008
Springer
13 years 6 months ago
A Model Checking Approach to the Parameter Estimation of Biochemical Pathways
Model checking has historically been an important tool to verify models of a wide variety of systems. Typically a model has to exhibit certain properties to be classed `acceptable&...
Robin Donaldson, David Gilbert
RECOMB
2005
Springer
13 years 10 months ago
Probabilistic in Silico Prediction of Protein-Peptide Interactions
Abstract. Peptide recognition modules (PRMs) are specialised compact protein domains that mediate many important protein-protein interactions. They are responsible for the assembly...
Wolfgang P. Lehrach, Dirk Husmeier, Christopher K....