Despite popular belief, boosting algorithms and related coordinate descent methods are prone to overfitting. We derive modifications to AdaBoost and related gradient-based coordin...
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
We present a method for designing efficient multigenic predictors with few probes and its application to the prediction of the response to preoperative chemotherapy in breast cance...
One central issue in system structuring and quality prediction is the interdependencies of system modules. This paper proposes a novel technique for determining the operational co...