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BMCBI
2010
88views more  BMCBI 2010»
13 years 5 months ago
Proteome scanning to predict PDZ domain interactions using support vector machines
Background: PDZ domains mediate protein-protein interactions involved in important biological processes through the recognition of short linear motifs in their target proteins. Tw...
Shirley Hui, Gary D. Bader
BMCBI
2010
159views more  BMCBI 2010»
13 years 5 months ago
Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines
Background: Protein-protein interaction (PPI) plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods ha...
Alvaro J. González, Li Liao
BMCBI
2008
134views more  BMCBI 2008»
13 years 5 months ago
Prediction of protein-protein binding site by using core interface residue and support vector machine
Background: The prediction of protein-protein binding site can provide structural annotation to the protein interaction data from proteomics studies. This is very important for th...
Nan Li, Zhonghua Sun, Fan Jiang
BIBE
2007
IEEE
142views Bioinformatics» more  BIBE 2007»
13 years 11 months ago
An HV-SVM Classifier to Infer TF-TF Interactions Using Protein Domains and GO Annotations
—Interactions between transcription factors (TFs) are necessary for deciphering the complex mechanisms of transcription regulation in eukaryotes. In this paper, we proposed a nov...
Xiaoli Li, Jun-Xiang Lee, Bharadwaj Veeravalli, Se...
BMCBI
2004
123views more  BMCBI 2004»
13 years 5 months ago
Interaction profile-based protein classification of death domain
Background: The increasing number of protein sequences and 3D structure obtained from genomic initiatives is leading many of us to focus on proteomics, and to dedicate our experim...
Drew Lett, Michael Hsing, Frederic Pio