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» SHAPE directed RNA folding
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BMCBI
2004
122views more  BMCBI 2004»
13 years 4 months ago
A comprehensive comparison of comparative RNA structure prediction approaches
Background: An increasing number of researchers have released novel RNA structure analysis and prediction algorithms for comparative approaches to structure prediction. Yet, indep...
Paul P. Gardner, Robert Giegerich
IPMI
2009
Springer
14 years 5 months ago
Oriented Morphometry of Folds on Surfaces
Abstract. The exterior surface of the brain is characterized by a juxtaposition of crests and troughs that together form a folding pattern. The majority of the deformations that oc...
Maxime Boucher, Alan C. Evans, Kaleem Siddiqi
DNA
2009
Springer
185views Bioinformatics» more  DNA 2009»
13 years 11 months ago
NP-Completeness of the Direct Energy Barrier Problem without Pseudoknots
Knowledge of energy barriers between pairs of secondary structures for a given DNA or RNA molecule is useful, both in understanding RNA function in biological settings and in desig...
Ján Manuch, Chris Thachuk, Ladislav Stacho,...
BMCBI
2008
123views more  BMCBI 2008»
13 years 5 months ago
Shape based indexing for faster search of RNA family databases
Background: Most non-coding RNA families exert their function by means of a conserved, common secondary structure. The Rfam data base contains more than five hundred structurally ...
Stefan Janssen, Jens Reeder, Robert Giegerich
BMCBI
2010
154views more  BMCBI 2010»
13 years 5 months ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...