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» SIMAP - structuring the network of protein similarities
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NAR
2010
148views more  NAR 2010»
9 years 9 days ago
SIMAP - a comprehensive database of pre-calculated protein sequence similarities, domains, annotations and clusters
The prediction of protein function as well as the reconstruction of evolutionary genesis employing sequence comparison at large is still the most powerful tool in sequence analysi...
Thomas Rattei, Patrick Tischler, Stefan Götz,...
ECCB
2005
IEEE
9 years 11 months ago
SIMAP - The similarity matrix of proteins
Similarity Matrix of Proteins (SIMAP) (http://mips.gsf. 10 de/simap) provides a database based on a precomputed similarity matrix covering the similarity space formed by .4 millio...
Roland Arnold, Thomas Rattei, Patrick Tischler, Mi...
BMCBI
2010
120views more  BMCBI 2010»
9 years 5 months ago
Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology
Background: In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centralit...
Kang Ning, Hoong Kee Ng, Sriganesh Srihari, Hon Wa...
BIOINFORMATICS
2007
161views more  BIOINFORMATICS 2007»
9 years 5 months ago
Functional evaluation of domain-domain interactions and human protein interaction networks
: Large amounts of protein and domain interaction data are being produced by experimental high-throughput techniques and computational approaches. To gain insight into the value of...
Andreas Schlicker, Carola Huthmacher, Fidel Ram&ia...
BIBM
2008
IEEE
175views Bioinformatics» more  BIBM 2008»
10 years 1 days ago
Integrative Protein Function Transfer Using Factor Graphs and Heterogeneous Data Sources
We propose a novel approach for predicting protein functions of an organism by coupling sequence homology and PPI data between two (or more) species with multifunctional Gene Onto...
Antonina Mitrofanova, Vladimir Pavlovic, Bud Mishr...
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