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» SNPs Problems, Complexity, and Algorithms
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BMCBI
2006
138views more  BMCBI 2006»
13 years 4 months ago
Approximation properties of haplotype tagging
Background: Single nucleotide polymorphisms (SNPs) are locations at which the genomic sequences of population members differ. Since these differences are known to follow patterns,...
Staal A. Vinterbo, Stephan Dreiseitl, Lucila Ohno-...
DMTCS
2003
99views Mathematics» more  DMTCS 2003»
13 years 6 months ago
Combinatorial Problems Arising in SNP and Haplotype Analysis
It is widely anticipated that the study of variation in the human genome will provide a means of predicting risk of a variety of complex diseases. This paper presents a number of a...
Bjarni V. Halldórsson, Vineet Bafna, Nathan...
WABI
2007
Springer
109views Bioinformatics» more  WABI 2007»
13 years 11 months ago
Two Birds, One Stone: Selecting Functionally Informative Tag SNPs for Disease Association Studies
Selecting an informative subset of SNPs, generally referred to as tag SNPs, to genotype and analyze is considered to be an essential step toward effective disease association studi...
Phil Hyoun Lee, Hagit Shatkay
BMCBI
2008
119views more  BMCBI 2008»
13 years 5 months ago
Snagger: A user-friendly program for incorporating additional information for tagSNP selection
Background: There has been considerable effort focused on developing efficient programs for tagging single-nucleotide polymorphisms (SNPs). Many of these programs do not account f...
Christopher K. Edlund, Won H. Lee, Dalin Li, David...
BMCBI
2005
157views more  BMCBI 2005»
13 years 4 months ago
Decision Forest Analysis of 61 Single Nucleotide Polymorphisms in a Case-Control Study of Esophageal Cancer; a novel method
Background: Systematic evaluation and study of single nucleotide polymorphisms (SNPs) made possible by high throughput genotyping technologies and bioinformatics promises to provi...
Qian Xie, Luke D. Ratnasinghe, Huixiao Hong, Roger...