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» SNPs3D: Candidate gene and SNP selection for association stu...
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BMCBI
2006
190views more  BMCBI 2006»
13 years 5 months ago
SNPs3D: Candidate gene and SNP selection for association studies
Background: The relationship between disease susceptibility and genetic variation is complex, and many different types of data are relevant. We describe a web resource and databas...
Peng Yue, Eugene Melamud, John Moult
BMCBI
2011
13 years 1 days ago
Predicting functionally important SNP classes based on negative selection
Background: With the advent of cost-effective genotyping technologies, genome-wide association studies allow researchers to examine hundreds of thousands of single nucleotide poly...
Mark A. Levenstien, Robert J. Klein
WABI
2007
Springer
109views Bioinformatics» more  WABI 2007»
13 years 11 months ago
Two Birds, One Stone: Selecting Functionally Informative Tag SNPs for Disease Association Studies
Selecting an informative subset of SNPs, generally referred to as tag SNPs, to genotype and analyze is considered to be an essential step toward effective disease association studi...
Phil Hyoun Lee, Hagit Shatkay
BMCBI
2011
13 years 1 days ago
Pathway-based analysis using reduced gene subsets in genome-wide association studies
Background: Single Nucleotide Polymorphism (SNP) analysis only captures a small proportion of associated genetic variants in Genome-Wide Association Studies (GWAS) partly due to s...
Jingyuan Zhao, Simone Gupta, Mark Seielstad, Jianj...
BMCBI
2005
105views more  BMCBI 2005»
13 years 5 months ago
SNPHunter: a bioinformatic software for single nucleotide polymorphism data acquisition and management
Background: Single nucleotide polymorphisms (SNPs) provide an important tool in pinpointing susceptibility genes for complex diseases and in unveiling human molecular evolution. S...
Lin Wang, Simin Liu, Tianhua Niu, Xin Xu