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BMCBI
2007
126views more  BMCBI 2007»
13 years 6 months ago
High-throughput identification of interacting protein-protein binding sites
Background: With the advent of increasing sequence and structural data, a number of methods have been proposed to locate putative protein binding sites from protein surfaces. Ther...
Jo-Lan Chung, Wei Wang, Philip E. Bourne
BMCBI
2010
145views more  BMCBI 2010»
13 years 1 months ago
Directionality in protein fold prediction
Background: Ever since the ground-breaking work of Anfinsen et al. in which a denatured protein was found to refold to its native state, it has been frequently stated by the prote...
Jonathan J. Ellis, Fabien P. E. Huard, Charlotte M...
BIBE
2007
IEEE
167views Bioinformatics» more  BIBE 2007»
13 years 10 months ago
Assessing the Performance of Macromolecular Sequence Classifiers
Machine learning approaches offer some of the most cost-effective approaches to building predictive models (e.g., classifiers) in a broad range of applications in computational bio...
Cornelia Caragea, Jivko Sinapov, Vasant Honavar, D...
APBC
2004
116views Bioinformatics» more  APBC 2004»
13 years 7 months ago
Structure-Function Relationship in DNA Sequence Recognition by Transcription Factors
Transcription factors play essential role in the gene regulation in higher organisms, binding to multiple target sequences and regulating multiple genes in a complex manner. In or...
Akinori Sarai, Samuel Selvaraj, M. Michael Gromiha...
JIB
2006
78views more  JIB 2006»
13 years 6 months ago
Prediction of transcription factor binding to DNA using rule induction methods
In this study, we seek to develop a predictive model for finding the strength of binding between a particular transcription factor (TF) variant and a particular DNA target variant...
Mikael Huss, Karin Nordström