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JCB
2000
91views more  JCB 2000»
13 years 4 months ago
Scaling Laws and Similarity Detection in Sequence Alignment with Gaps
We study the problem of similarity detection by sequence alignment with gaps, using a recently established theoretical framework based on the morphology of alignment paths. Alignm...
Dirk Drasdo, Terence Hwa, Michael Lässig
BMCBI
2007
147views more  BMCBI 2007»
13 years 5 months ago
MaxAlign: maximizing usable data in an alignment
Background: The presence of gaps in an alignment of nucleotide or protein sequences is often an inconvenience for bioinformatical studies. In phylogenetic and other analyses, for ...
Rodrigo Gouveia-Oliveira, Peter Wad Sackett, Ander...
BMCBI
2010
121views more  BMCBI 2010»
13 years 5 months ago
MS4 - Multi-Scale Selector of Sequence Signatures: An alignment-free method for classification of biological sequences
Background: While multiple alignment is the first step of usual classification schemes for biological sequences, alignment-free methods are being increasingly used as alternatives...
Eduardo Corel, Florian Pitschi, Ivan Laprevotte, G...
BMCBI
2010
129views more  BMCBI 2010»
13 years 5 months ago
Detection of distant evolutionary relationships between protein families using theory of sequence profile-profile comparison
Background: Detection of common evolutionary origin (homology) is a primary means of inferring protein structure and function. At present, comparison of protein families represent...
Mindaugas Margelevicius, Ceslovas Venclovas
BIBE
2005
IEEE
126views Bioinformatics» more  BIBE 2005»
13 years 10 months ago
Highly Scalable and Accurate Seeds for Subsequence Alignment
We propose a method for finding seeds for the local alignment of two nucleotide sequences. Our method uses randomized algorithms to find approximate seeds. We present a dynamic ...
Abhijit Pol, Tamer Kahveci