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PPSN
2004
Springer
13 years 10 months ago
Searching Transcriptional Modules Using Evolutionary Algorithms
The mechanism of gene regulation has been studied intensely for decades. It is important to identify synergistic transcriptional motifs. Its search space is so large that an effici...
Je-Gun Joung, Sok June Oh, Byoung-Tak Zhang
GECCO
2007
Springer
153views Optimization» more  GECCO 2007»
13 years 10 months ago
Analyzing the effects of module encapsulation on search space bias
Modularity is thought to improve the evolvability of biological systems [18, 22]. Recent studies in the field of evolutionary computation show that the use of modularity improves...
Ozlem O. Garibay, Annie S. Wu
WABI
2009
Springer
128views Bioinformatics» more  WABI 2009»
13 years 11 months ago
Improving Inference of Transcriptional Regulatory Networks Based on Network Evolutionary Models
Abstract. Computational inference of transcriptional regulatory networks remains a challenging problem, in part due to the lack of strong network models. In this paper we present e...
Xiuwei Zhang, Bernard M. E. Moret
BMCBI
2007
186views more  BMCBI 2007»
13 years 4 months ago
Modeling human cancer-related regulatory modules by GA-RNN hybrid algorithms
Background: Modeling cancer-related regulatory modules from gene expression profiling of cancer tissues is expected to contribute to our understanding of cancer biology as well as...
Jung-Hsien Chiang, Shih-Yi Chao
BMCBI
2008
133views more  BMCBI 2008»
13 years 4 months ago
CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated
Background: The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false po...
Matthew S. Hestand, Michiel van Galen, Michel P. V...